Figure 4. Mitochondrial dysfunction in the hypoxia-treated C28/I2 cells, post the RhoA overexpression.

C28/I2 cells were transfected with pcDNA-RhoA or with pcDNA-Con and were inoculated under hypoxia for 24 or 48 h and then the percentage of mitochondrial superoxide levels (A), of ROS level (B), of MMP (C) and of Complex IV activity (D) were assayed respectively. All results were averaged for three independent experiments. *P<0.05, **P<0.01 or ***P<0.001.