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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Brain Res. 2017 Mar 2;1662:75–86. doi: 10.1016/j.brainres.2017.02.027

Figure 1.

Figure 1

Effects of single, acute administration of Mesyl Salvinorin B (MSB, 3 mg/kg) or naltrexone (NTN, 2mg/kg) on 15% alcohol intake, water intake, and preference ratio in male and female mice after 3-week chronic escalation drinking (CED). (1) Control groups (n=6–8): males and females received one vehicle injection (1% DMSO for MSB control, or saline for NTN control, i.p.) before the drinking test; (2) MSB groups: males (n=6–8) and females (n=14) received one MSB injection (3 mg/kg in 1% DMSO, i.p.) 30 min before the drinking test; and (3) NTN group: males (n=6) and females (n=8) received one NTN injection (2 mg/kg in saline, i.p.) 10 min before the drinking test. On the test day, alcohol (15%) and water intake values were recorded after 4, 8 and 24 hours of alcohol access. * p<0.05, **p<0.01 and ***p<0.005 vs. control at the same time point (see the statistical analysis in Supporting Information section).