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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Brain Res. 2017 Mar 2;1662:75–86. doi: 10.1016/j.brainres.2017.02.027

Figure 2.

Figure 2

Dose responses of single, acute administration of Mesyl Salvinorin B (MSB, 0, 0.1, 0.3, 1 or 3 mg/kg) alone or combined with naltrexone (NTN, 0, 0.3 or 1 mg/kg) on reducing 15% alcohol intake (A) and alcohol preference (B) in both male and female mice (n=5–8) after 3-week chronic escalation drinking. Data were collected at the 4-hour time point on the baseline and testing day (24 hours later) and are expressed as a percentage of baseline alcohol intake to account for the differences in baseline that contribute to variation between experiments. **p<0.01 vs. control (both MSB and NTN at 0 mg/kg); ## p<0.01 between treatment groups (see the statistical analysis in Supporting Information section).