Table 2.
No effects of single, acute administration of Mesyl Salvinorin B (MSB, 3mg/kg) (A), naltrexone (NTN, 2mg/kg) (B), or their combinations (0.3mg/kg MSB+1mg/kg NTN or 1mg/kg MSB+1mg/kg NTN) (C) on total fluid intake in male and female mice after 3-week chronic escalation drinking (CED).
| A. | ||||
|---|---|---|---|---|
| Total fluid intake, ml | male (n=6–8) | female (n=8–14) | ||
| Vehicle | 3mg/kg MSB | Vehicle | 3mg/kg MSB | |
| 0–4h | 1.6 ± 0.1 | 1.6 ± 0.2 | 1.9 ± 0.1 | 1.6 ± 0.2 |
| 5–8h | 1.0 ± 0.1 | 1.2 ± 0.3 | 1.7 ± 0.2 | 1.5 ± 0.3 |
| 9–24h | 2.8 ± 0.3 | 2.8 ± 0.4 | 3.0 ± 0.4 | 3.1 ± 0.5 |
| B. | ||||
|---|---|---|---|---|
| Total fluid intake, ml | male (n=6–8) | female (n=6–8) | ||
| Vehicle | 2mg/kg NTN | Vehicle | 2mg/kg NTN | |
| 0–4h | 1.9 ± 0.2 | 1.6 ± 0.2 | 1.6 ± 0.1 | 1.3 ± 0.1 |
| 5–8h | 1.4 ± 0.2 | 1.5 ± 0.3 | 1.9 ± 0.2 | 1.4 ± 0.4 |
| 9–24h | 3.0 ± 0.4 | 3.1 ± 0.5 | 3.2 ± 0.3 | 3.2 ± 0.5 |
| C. | ||||
|---|---|---|---|---|
| Total fluid intake, ml | female (n=6–8) | female (n=6–8) | ||
| Vehicle | 0.3 mg/kg MSB+ 1mg/kg NTN | Vehicle | 0.3 mg/kg MSB+ 1mg/kg NTN | |
| 0–4h | 1.5 ± 0.1 | 1.2 ± 0.2 | 1.5 ± 0.1 | 1.3 ± 0.2 |
| 5–8h | 1.2 ± 0.3 | 1.9 ± 0.4 | 1.5 ± 0.2 | 1.8 ± 0.5 |
| 9–24h | 3.5 ± 0.5 | 3.4 ± 0.5 | 3.7 ± 0.6 | 3.2 ± 0.3 |