Table 4.

No effect of single, acute administration of Mesyl Salvinorin B (MSB, 3 mg/kg) alone or the combination of MSB (0.3 mg/kg) and naltrexone (NTN, 1 mg/kg) on 4% sucrose (A and B) or 0.1% saccharin (C and D) intake, water intake and their preference ratio in male or female mice (n=6–7).

A	male		female
Treatment	Vehicle	3 mg/kg MSB	Vehicle	3 mg/kg MSB
Sucrose (4%) intake (g/kg/4h)	11.8 ± 0.81	9.5 ± 1.3	12.1 ± 1.75	13.7 ± 1.1
Water intake (ml/4h)	0.17 ± 0.06	0.23 ± 0.08	0.11 ± 0.02	0.19 ± 0.10
Preference ratio	0.98 ± 0.02	0.95 ± 0.02	0.98 ± 0.01	0.97 ± 0.02

B	male		female
Treatment	Vehicle + Saline	0.3 mg/kg MSB + 1 mg/kg NTN	Vehicle + Saline	0.3 mg/kg MSB + 1 mg/kg NTN
Sucrose (4%) intake (g/kg/4h)	9.9 ± 1.2	9.1 ± 1.0	11.5 ± 0.95	10.1 ± 1.10
Water intake (ml/4h)	0.13 ± 0.06	0.20 ± 0.05	0.15 ± 0.05	0.19 ± 0.11
Preference ratio	0.98 ± 0.02	0.97 ± 0.01	0.98 ± 0.01	0.98 ± 0.02

C	male		female
Treatment	Vehicle	3 mg/kg MSB	Vehicle	3 mg/kg MSB
Saccharin (0.1%) intake (g/kg/4h)	0.13 ± 0.03	0.11 ± 0.03	0.17 ± 0.02	0.19 ± 0.01
Water intake (ml/4h)	0.19 ± 0.10	0.26 ± 0.09	0.10 ± 0.04	0.16 ± 0.06
Preference ratio	0.95 ± 0.05	0.98 ± 0.05	0.97 ± 0.01	0.99 ± 0.01

D	male		female
Treatment	Vehicle + Saline	0.3 mg/kg MSB + 1 mg/kg NTN	Vehicle + Saline	0.3 mg/kg MSB + 1 mg/kg NTN
Saccharin (0.1%) intake (g/kg/4h)	0.17 ± 0.02	0.14 ± 0.07	0.19 ± 0.02	0.15 ± 0.06
Water intake (ml/4h)	0.15 ± 0.04	0.20 ± 0.09	0.14 ± 0.03	0.19 ± 0.06
Preference ratio	0.98 ± 0.02	0.98 ± 0.03	0.97 ± 0.01	0.98 ± 0.04