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. 2017 Feb 10;50(4):814–822. doi: 10.1021/acs.accounts.6b00598

Figure 6.

Figure 6

“Pulling factor” k, empirically defined as the slope of linear correlation between ΔΔG and insertion length, for each transition along the NMDAR activation pathway. (A) Plots correlating ΔΔG (kcal mol–1) and insertion length for GluN2A in the C2 → C1 transition. Also shown is the slope k, in kcal mol–1 nm–1, for linear fits to the first three (black) or four (gray) points. (B) Pulling factors, using three-point analysis, for all the transitions along the activation pathway. C1, C2, C3, O1, and O2 denote kinetic substates along the activation pathway. Reproduced with permission from ref (18). Copyright 2014 Nature Publishing Group.