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Cleft-semiclosed conformations, possibly characetristic of GluN1 and GluN2A LBDs in the channel-closed state. With the D1 subdomains superimposed, the D2 subdomains exhibit significant dispacements in putative semiclosed LBD conformations (GluN1 marine and GluN2A magenta) relative to the cleft-closed conformations (gray). Inset: distinct intersubdomain hydrogen bonds in cleft-closed and semiclosed LBDs. Conformations from ref (35).
