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. 2017 Mar 10;11:1177625017691937. doi: 10.1177/1177625017691937

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — The 3 arrows on the top-right corner of the figure represent, respectively, modifications (actions of a molecule on another, such as phosphorylation and ubiquitination, with positive results), inhibitions (negative effect of a molecule on another), and translocations (movement of a molecule from one compartment to another). An additional dashed line arrow is available for adding narrative clues with no specific biomolecular counterpart. The symbols at the bottom of the figure represent from left to right small molecules (eg, metabolites or drugs), proteins, gene-related material (eg, DNA, RNA, messenger RNA, and microRNA), raw material to represent de novo synthesis and degradation of components, and generic node to model whatever cannot be modeled with the previous node types.