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. 2017 Mar 10;11:1177625017691937. doi: 10.1177/1177625017691937

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — The visible model is an excerpt of the KEGG (Kyoto Encyclopedia of Genes and Genomes) FoxO signaling pathway in humans as appears after importing in bStyle. The 2 screenshots show the parameterizations for 2 different selected objects that bStyle highlights with an orange border. (A) Transforming growth factor receptor (TGF-βR) on the cytomembrane is selected and the toolbar presents its configurable details. New subclassification user interface levels are available from the toolbar to fulfill user’s need for fine-grained properties. In this case, the click sequence of the user was “Modifications” in toolbar, “Modification” in the selection list, and then “Phosphorylation” from a complete list of possible covalent protein modification statuses. (B) The TGF-β signaling pathway, that KEGG simplifies to a horizontal cascade arrow, is presented accordingly in the model and in its counterpart toolbar representation, showing the intervention of SMAD4 to result in SMAD3.