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. Author manuscript; available in PMC: 2018 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Mar 1;27(8):1731–1736. doi: 10.1016/j.bmcl.2017.02.073

Table 3.

HIF Inhibition by Class 1B analogues

graphic file with name nihms859605u3.jpg
Name R3 IC50[a]
4a graphic file with name nihms859605t8.jpg 1
4b graphic file with name nihms859605t9.jpg >5
4c graphic file with name nihms859605t10.jpg >5
4d graphic file with name nihms859605t11.jpg >5
4e graphic file with name nihms859605t12.jpg 0.610
4f[b] graphic file with name nihms859605t12.jpg 3.2
[a]

IC50 values are in micromolar (μM).

[b]

A ring is hydrogenated 2,2-dimethylpyranobenzene.

HHS Vulnerability Disclosure