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. Author manuscript; available in PMC: 2018 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Mar 1;27(8):1731–1736. doi: 10.1016/j.bmcl.2017.02.073

Table 4.

HIF Inhibition by Class 1C analogues

graphic file with name nihms859605u4.jpg
Name R2 R3 IC50[a]
5a graphic file with name nihms859605t13.jpg graphic file with name nihms859605t14.jpg 0.75
5b graphic file with name nihms859605t15.jpg >5
5c graphic file with name nihms859605t9.jpg >5
5d graphic file with name nihms859605t16.jpg >5
5e graphic file with name nihms859605t10.jpg 4.6
5f graphic file with name nihms859605t17.jpg 4.4
5g graphic file with name nihms859605t18.jpg graphic file with name nihms859605t19.jpg 1.5
5h graphic file with name nihms859605t17.jpg >5
5i graphic file with name nihms859605t20.jpg 3.0
5j graphic file with name nihms859605t14.jpg 0.5
5k graphic file with name nihms859605t21.jpg graphic file with name nihms859605t14.jpg 4.0
5l[b] graphic file with name nihms859605t14.jpg >5
5m[b] graphic file with name nihms859605t13.jpg graphic file with name nihms859605t14.jpg 0.39
[a]

IC50 values are in micromolar (μM).

[b]

A ring is hydrogenated 2,2-dimethylpyranobenzene.

HHS Vulnerability Disclosure