Table 1.
Proteins identified from vitreous of control and PDR subjects.
| Accession number—International Protein Index (IPI) | Name of the proteins in PDR vitreous only | Biological functions |
|---|---|---|
| IPI00021885 | Isoform 1 of fibrinogen alpha chain | Coagulation |
| IPI00298497 | Fibrinogen beta chain | Coagulation |
| IPI00166729 | Zinc-alpha-2-glycoprotein | Associated with insulin resistance, lipid metabolism |
| IPI00032328 | Isoform high molecular weight of kininogen-1 | Kinin-kallikrein system, inflammation, angiogenesis |
| IPI00022371 | Histidine-rich glycoprotein | Antifibrinolytic activity |
| IPI00654755 | Hemoglobin subunit beta | Binding |
| IPI00291867 | Complement factor I | Complement system |
| IPI00410714 | Hemoglobin subunit alpha | Transport |
| IPI00014048 | Ribonuclease pancreatic | Enzyme, involved in binding |
| IPI00029658 | Isoform 1 of EGF-containing fibulin-like extracellular matrix | Involved in visual perception, binding, signaling |
| IPI00019568 | Prothrombin | Coagulation (thrombotic risk) |
| IPI00022426 | Protein AMBP | Protease inhibitor, binding activity |
| IPI00298971 | Vitronectin | Coagulation cascade |
| IPI00027765 | Isoform 2 of retbindin | Photoreceptor-specific protein |
| IPI00021891 | Isoform gamma-B of fibrinogen gamma chain | Coagulation, transport, signaling |
| IPI00006608 | Isoform APP770 of amyloid beta A4 protein | Cytoskeleton, binding, transport |
| Accession number—IPI | Name of proteins in control vitreous only | Biological functions |
| IPI00006114 | PEDF | Antiangiogenic, cell proliferation |
| IPI00022337 | Retinol-binding protein 3 | Fatty acid transport, Visual cycle |
| IPI00022429 | Alpha-1-acid glycoprotein 1 | Acute phase inflammatory reactant |
| IPI00020091 | Alpha-1-acid glycoprotein 2 | Acute phase inflammatory reactant |
| IPI00002678 | Opticin | Receptor, adhesion, signaling |
| IPI00022432 | Transthyretin | Transport, signaling |
| IPI00289999 | Collagen alpha-3(IX) chain | Peptide hormone, transport, binding, signaling, intercellular |
| IPI00186460 | Isoform 1 of collagen alpha-1(II) chain | Peptide hormone, transport, binding, signaling, intercellular |
| IPI00019088 | Collagen alpha-2(IX) chain | Peptide hormone, transport, binding, signaling, intercellular |
| IPI00218539 | Isoform B of collagen alpha-1(XI) chain | Peptide hormone, transport, binding, signaling, intercellular |
| IPI00031030 | Isoform 1 of amyloid-like protein 2 | Involved in binding and signaling |
| IPI00021000 | Isoform A of osteopontin | Immunomodulation, angiogenesis |
| IPI00387118 | Ig kappa chain V-III region WOL | Binding |
| IPI00011229 | Cathepsin D | Signaling, proteases |
| IPI00032179 | Antithrombin III | Coagulation system |
| Accession number—IPI | Proteins present in both PDR and control vitreous | Biological functions |
| IPI00745872 | Isoform 1 of serum albumin | Transport |
| IPI00022463 | Serotransferrin | Transport |
| IPI00291262 | Isoform 1 of clusterin | Immune response |
| IPI00168728 | Cluster of FLJ00385 protein | |
| IPI00553177 | Isoform1 of alpha-1-antitrypsin | Coagulation |
| IPI00645363 | Putative uncharacterized protein DKFZp686P15220 | |
| IPI00022431 | cDNA FLJ55606, highly similar to alpha-2-HS-glycoprotein | Intercellular, binding |
| IPI00641737 | Haptoglobin | Binding |
| IPI00013179 | Prostaglandin-H2 d-isomerase | Biosynthesis, transport |
| IPI00555812 | Vitamin D–binding protein isoform 1 precursor | Transport and cargo |
| IPI00021841 | Apolipoprotein A-I | Transport |
| IPI00298828 | Beta-2-glycoprotein 1 | |
| IPI00021854 | Apolipoprotein A-II | Transport |
| IPI00022895 | Isoform 1 of alpha-1B-glycoprotein | Receptor, signaling |
| IPI00002714 | cDNA FLJ52545, highly similar to Dickkopf-related protein 3 | Signaling |
| IPI00304273 | Apolipoprotein A-IV | Transport |
| IPI00021842 | Apolipoprotein E | Transport |
| IPI00032293 | Cystatin-C | Protease inhibitor, binding |
| IPI00032258 | Complement C4-A | Immune response |
| IPI00022488 | Hemopexin | Transport |
| IPI00783987 | Complement C3 | Immune response |
| IPI00019591 | cDNA FLJ55673, highly similar to complement factor B | Immune response |
| IPI00215894 | Isoform LMW of kininogen-1 | Kallikrein-kinin system |
| IPI00017601 | Ceruloplasmin | Transport, binding |
| IPI00478003 | Alpha-2-macroglobulin | Coagulation |
| IPI00026314 | Isoform 1 of gelsolin | Cytoskeleton, binding, intercellular |
Abbreviations: AMBP, alpha-1-microglobulin/bikunin precursor; EGF, epidermal growth factor; LMW, low molecular weight; PDR, proliferative diabetic retinopathy; PEDF, pigment epithelium–derived factor.