Table 2.
Vitreous proteins that participate in complement, coagulation, and kinin-kallikrein system.
| S. no. | Name of the protein | International Protein Index (IPI) | Sequence coverage—control (%) | Sequence coverage—PDR (%) |
|---|---|---|---|---|
| 1 | Complement C4-A | IPI00032258 | 7.2 | 7.3 |
| 2 | Complement C3 | IPI00783987 | 5.1 | 4.1 |
| 3 | cDNA FLJ55673, highly similar to complement factor B | IPI00019591 | 4 | 8.5 |
| 4 | Complement factor I | IPI00291867 | 0 | 6.9 |
| 5 | Clusterin | IPI00291262 | 39 | 26 |
| Coagulation system | ||||
| 6 | Isoform 1 of alpha-1-antitrypsin | IPI00553177 | 48 | 5.7 |
| 7 | Isoform 1 of fibrinogen alpha chain | IPI00021885 | 0 | 29 |
| 8 | Fibrinogen beta chain | IPI00298497 | 0 | 18 |
| 9 | Alpha-2-macroglobulin | IPI00478003 | 3 | 1.6 |
| 10 | Prothrombin | IPI00019568 | 0 | 8.5 |
| 11 | Isoform gamma-B of fibrinogen gamma chain | IPI00021891 | 0 | 12 |
| 12 | Antithrombin III | IPI00032179 | 6.2 | 0 |
| 13 | Histidine-rich glycoprotein | IPI00022371 | 0 | 9.9 |
| Kinin-kallikrein system | ||||
| 14 | Isoform LMW of kininogen-1 | IPI00215894 | 6.1 | 14 |
| 15 | Isoform HMW of kininogen-1 | IPI00032328 | 0 | 4.7 |
Abbreviations: HMW, high molecular weight; LMW, low molecular weight; PDR, proliferative diabetic retinopathy.