Table 3.
Proteins identified from aqueous of control and PDR subjects.
| S. no. | Name of the protein | Accession number—International Protein Index (IPI) | Biological functions | Sequence coverage (%) | |
|---|---|---|---|---|---|
| Control | PDR | ||||
| 1 | Isoform 1 of serum albumin | IPI00745872 | Transport | 77 | 91 |
| 2 | Serotransferrin | IPI00022463 | Transport | 54 | 71 |
| 3 | Isoform 1 of clusterin | IPI00291262 | Immune response | 6.90 | 17 |
| 4 | Cluster of FLJ00385 protein (fragment) | IPI00168728 | 24 | 43 | |
| 5 | Putative uncharacterized protein DKFZp686P15220 | IPI00645363 | 24 | 43 | |
| 6 | Similar to hepatitis B virus receptor-binding protein | IPI00977788 | 0 | 26 | |
| 7 | Isoform 1 of alpha-1-antitrypsin | IPI00553177 | Coagulation | 12 | 18 |
| 8 | cDNA FLJ55606, highly similar to alpha-2-HS-glycoprotein | IPI00022431 | Binding, intercellular | 11 | 16 |
| 9 | Haptoglobin | IPI00641737 | Binding | 18 | 39 |
| 10 | Prostaglandin-H2 d-isomerase | IPI00013179 | Biosynthesis, transport | 38 | 34 |
| 11 | Vitamin D–binding protein isoform 1 precursor | IPI00555812 | Transport and cargo protein | 15 | 30 |
| 12 | Apolipoprotein A-I | IPI00021841 | Transport | 0 | 21 |
| 13 | Isoform 1 of fibrinogen alpha chain | IPI00021885 | Coagulation | 0 | 2.20 |
| 14 | Beta-2-glycoprotein 1 | IPI00298828 | 11 | 22 | |
| 15 | Apolipoprotein A-II | IPI00021854 | Transport | 0 | 72 |
| 16 | Isoform 1 of alpha-1B-glycoprotein | IPI00022895 | 22 | 36 | |
| 17 | Cluster of cDNA FLJ52545, highly similar to Dickkopf-related protein 3 (IPI00002714) | IPI00002714 | Signaling | 12 | 9.10 |
| 18 | Uncharacterized protein | IPI00971192 | 12 | 9.10 | |
| 19 | Pigment epithelium–derived factor | IPI00006114 | Cell proliferation, antiangiogenic | 5.00 | 11 |
| 20 | Cystatin-C | IPI00032293 | Protease inhibitor, binding | 40 | 25 |
| 21 | Complement C4-A | IPI00032258 | Immune response | 2.50 | 5.70 |
| 22 | Hemopexin | IPI00022488 | Transport | 13 | 19 |
| 23 | Complement C3 (fragment) | IPI00783987 | Immune response | 1.9 | 4.7 |
| 24 | cDNA FLJ55673, highly similar to complement factor B | IPI00019591 | Immune response | 3.3 | 3.50 |
| 25 | Fibrinogen beta chain | IPI00298497 | Coagulation | 0 | 5.30 |
| 26 | Apolipoprotein A-IV | IPI00304273 | Transport | 0 | 6.60 |
| 27 | Zinc-alpha-2-glycoprotein | IPI00166729 | Fatty acid binding, ribonuclease activity | 9.70 | 0 |
| 28 | Alpha-1-acid glycoprotein 1 | IPI00022429 | Inflammatory protein | 0 | 12 |
| 29 | Isoform LMW of kininogen-1 | IPI00215894 | Kinin-kallikrein system | 9.10 | 12 |
| 30 | Ceruloplasmin | IPI00017601 | Transport, binding | 0 | 6.30 |
| 31 | Histidine-rich glycoprotein | IPI00022371 | Antifibrinolytic activity | 9.70 | 0 |
| 32 | Transthyretin | IPI00022432 | Transport | 14 | 41 |
| 33 | Alpha-2-macroglobulin | IPI00478003 | Coagulation | 0 | 1.60 |
| 34 | Retinol-binding protein 4 | IPI00022420 | Visual cycle | 9.50 | 9.50 |
| 35 | Ig kappa chain V-III region WOL | IPI00387118 | Binding | 22 | 25 |
| 36 | Insulin-like growth factor–binding protein 7 | IPI00016915 | Cell adhesion | 17 | 0 |
| 37 | Similar to Ig kappa chain V-III region VG precursor | IPI00977405 | 0 | 30 | |
| 38 | Protein AMBP | IPI00022426 | Protease inhibitor, binding | 7.70 | 0 |
| 39 | Myosin-reactive immunoglobulin kappa chain variable region (fragment) | IPI00384401 | 25 | 31 | |
Abbreviations: AMBP, alpha-1-microglobulin/bikunin precursor; LMW, low molecular weight; PDR, proliferative diabetic retinopathy; PEDF, pigment epithelium–derived factor.