Table 4.

Reported prognostic factors for survival and risk factors for adverse reactions

Prognostic factor for overall survival

Debulking surgery prior to reirradiation

Anatomic site

Histology

Time interval since prior treatment

Second primary versus recurrent tumor

Dose–response relationship

Tumor size (T category)/volume of reirradiation

Treatment modality

Gender

Salvage treatment

Age

Risk factor for adverse reactions

Accumulated irradiated dose

Concurrent use of chemotherapy

Age

Mucosal involvement/ulceration

Treatment volume

Reirradiation schedule

Treatment modalities