Table 2.
Significantly altered genes in peripheral blood mononuclear cells 2 hours after vorinostat administration
| Gene | Fold-changea) | q-valueb) |
|---|---|---|
| HSPA1B | 4.2 | 4.1 |
| PHF13 | 3.8 | 1.6 |
| PTTG1 | 3.5 | 4.1 |
| ING2 | 3.5 | 3.3 |
| C17ORF91 | 3.2 | 1.6 |
| TNFRSF12A | 3.1 | 2.8 |
| SPATA2L | 3.1 | 7.7 |
| PTTG3P | 3.0 | 4.7 |
| PTTG1 | 3.0 | 9.4 |
| ADRB2 | 2.7 | 4.7 |
| ZC3H12A | 2.7 | 0 |
| MSH6 | 2.6 | 5.9 |
| C16ORF61 | 2.6 | 3.7 |
| GADD45B | 2.6 | 4.1 |
| CKS2 | 2.5 | 4.1 |
| ZNF791 | 2.5 | 2.8 |
| SGK | 0.30 | 0 |
| DEFA3 | 0.30 | 6.7 |
| DEFA1B | 0.30 | 7.7 |
| DEFA1 | 0.30 | 5.9 |
| LOC653600 | 0.30 | 7.7 |
| ZC3HC1 | 0.30 | 0 |
| GIMAP8 | 0.30 | 0 |
| MS4A7 | 0.40 | 1.5 |
| MYC | 0.40 | 1.6 |
| IL27RA | 0.40 | 0.72 |
| PDK4 | 0.40 | 0.72 |
| MYC | 0.40 | 2.8 |
| CYP1B1 | 0.40 | 2.7 |
a)
Fold-change from baseline expression,
b)
q-value represents an adjusted p-value, the lowest false discovery rate at which the gene is deemed to have changed significantly.