Table 3.
Enriched biological processes in peripheral blood mononuclear cells 2 hours after vorinostat administration (400 mg)
| Gene ontology (GO) term | p-value | Gene |
|---|---|---|
| Induced process | ||
| GO:0051276 chromosome organisation |
1.5×10-5 | UTP3, HIST2H2AA3, ING2, RBM4, CBX4, CBX3, TERF2IP, PTTG1, HIST2H4A, CBX6, BRPF1, TSPYL2, SMARCD2, H2AFZ, HIST3H2A, BCOR, KDM5B, BUB3, PINX1, MLL, MSH3, HIST1H1C, TAF5, PTTG3P, NASP, H2AFJ, DAPK3, C20ORF20, JMJD6, BCORL1, RRS1, H3F3B, SETD8, RBM14 |
| GO:0008219 cell death |
3.1×10-5 | MICB, PPARD, HRAS, TNF, TNFRSF12A, PMAIP1, MTP18, PDCD1, GLRX2, SETX, RRAGC, BAG5, BAK1, HTRA2, TARDBP, DAD1, ZC3H12A, PSENEN, BMF, CASP2, TRAF4, MLL, SRA1, TBRG4, POLB, DAPK3, ELMO2, PLEKHF1, TNFRSF10C, TNFRSF10B, AKTIP, JMJD6, TDP1, BAX, SLC5A8, APAF1, HSPD1, GADD45B, CLN8, PPP1R15A, UBA52, MAP3K11 |
| GO:0016265 death |
3.6×10-5 | MICB, PPARD, HRAS, TNF, TNFRSF12A, PMAIP1, MTP18, PDCD1, GLRX2, SETX, RRAGC, BAG5, BAK1, HTRA2, TARDBP, DAD1, ZC3H12A, PSENEN, BMF, CASP2, TRAF4, MLL, SRA1, TBRG4, POLB, DAPK3, ELMO2, PLEKHF1, TNFRSF10C, TNFRSF10B, AKTIP, JMJD6, TDP1, BAX, SLC5A8, APAF1, HSPD1, GADD45B, CLN8, PPP1R15A, UBA52, MAP3K11 |
| GO:0006325 chromatin organisation |
1.2×10-4 | UTP3, HIST2H2AA3, ING2, RBM4, CBX4, CBX3, HIST2H4A, CBX6, BRPF1, TSPYL2, SMARCD2, H2AFZ, HIST3H2A, BCOR, KDM5B, MLL, HIST1H1C, TAF5, NASP, H2AFJ, DAPK3, C20ORF20, BCORL1, JMJD6, H3F3B, SETD8, RBM14 |
| GO:0006915 apoptosis |
1.8×10-4 | HRAS, PPARD, TNF, TNFRSF12A, PMAIP1, MTP18, PDCD1, GLRX2, RRAGC, BAG5, BAK1, HTRA2, DAD1, ZC3H12A, PSENEN, BMF, CASP2, TRAF4, MLL, SRA1, TBRG4, DAPK3, ELMO2, PLEKHF1, TNFRSF10C, TNFRSF10B, AKTIP, JMJD6, BAX, SLC5A8, APAF1, HSPD1, GADD45B, PPP1R15A, UBA52 |
| Repressed process | ||
| GO:0006396 RNA processing |
6.7×10-8 | RNASEN, RNASEL, CRNKL1, GAR1, DICER1, DUSP11, POLR2C, XAB2, EXOSC10, INTS9, SFRS6, RBM4B, SFRS4, DHX38, AGGF1, QTRTD1, TRMT5, RBM10, RBM28, GEMIN4, DUS3L, RBM22, PPP2R1A, RBM23, CSTF2, C1ORF25, DDX1, HEATR1, CDC5L, SF3A1, TRMT61A, RBMX, URM1, PHAX, PPIE, PPP1R8, GTF2F1, CPSF3, CWC22, UTP14A, TRUB2, RPP40, RBM16, DUS2L, KIAA1429 |
| GO:0006350 transcription |
3.3×10-7 | CNOT2, MED24, APOBEC3G, GTF2IRD2B, EPC1, EPC2, OLIG1, ZNF593, ZNF45, ZHX2, ZNF37A, ZNF193, MGA, DEAF1, ZNF613, TH1L, KEAP1, XAB2, SMARCB1, ZNF329, LEO1, ZNF426, RNF14, SETDB1, TAF4, IKZF3, IKZF1, RFX5, MAFB, KLF11, SUV39H1, KAT5, HOXB2, ZNF211, ZNF317, GTF2F1, DNMT1, KLF2, ZNF85, TAF1C, CRCP, CTCF, ZEB2, DMAP1, RFXANK, ZKSCAN4, C10ORF137, ZNF350, ASH2L, CCDC101, E4F1, MKL1, MYC, ELP3, MTERF, GMEB2, GMEB1, ZNF543, ZNF142, CDK7, MCM2, CDC5L, ZNF689, ZNF688, ZNF140, PCGF1, ZFP37, MED6, ZNF341, ZNF134, NCOA5, NCOA6, ZNF274, ING3, NMI, ZNF559, ZNF805, NFYC, HCFC1, ZNF35, ZNF366, ZNF653, POLR2C, CCDC59, ZNF32, ZNF708, ECD, ZNF473, GTF3C6, THAP1, GTF3C2, ERCC3, GTF3C1, TRIP11, ZNF605, GTF3C3, ZNF565, CEBPB, HSFX1, L3MBTL2, ZNF260, ZNF23, IRF9, PHF17, ADNP2, RPAP1, UBTF, ZNF362, SP2, PPP1R8, RBM16, VPS25 |
| GO:0016071 mRNA metabolic process |
2.7×10-6 | RNASEL, C17ORF71, CRNKL1, XAB2, POLR2C, ZFP36L1, EXOSC10, SFRS6, DCPS, RBM4B, SFRS4, DHX38, RBM10, RBM28, GEMIN4, RBM22, RBM23, CSTF2, DDX1, ZHX2, CDC5L, SF3A1, RBMX, PHAX, PPIE, PPP1R8, DCP1A, GTF2F1, CPSF3, CWC22, RBM16, KIAA1429 |
| GO:0006351 transcription, DNA-dependent |
1.8×10-5 | DEAF1, TAF1C, NMI, CRCP, MED24, HCFC1, POLR2C, ASH2L, ECD, GTF3C6, ERCC3, GTF3C2, MYC, TRIP11, GTF3C1, GTF3C3, TAF4, MTERF, CEBPB, GMEB2, KLF11, CDK7, IRF9, GTF2F1, NCOA6, RBM16 |
| GO:0032774 RNA biosynthetic process |
2.2×10-5 | DEAF1, TAF1C, NMI, CRCP, MED24, HCFC1, POLR2C, ASH2L, ECD, GTF3C6, ERCC3, GTF3C2, MYC, TRIP11, GTF3C1, GTF3C3, TAF4, MTERF, CEBPB, GMEB2, KLF11, CDK7, IRF9, GTF2F1, NCOA6, RBM16 |