Table 3.
Coefficients and risk points of each genetic predictor for grade ≥ 2 fibrosis in Cox regression models
| Predictor | Beta | HR (95% CI) | p-value | Risk score |
|---|---|---|---|---|
| Model 1 | ||||
| Mitochondrial haplogroup | ||||
| H | Reference | 1 | 0 | |
| Non-H | 0.71 | 2.04 (1.12-3.72) | 0.02 | 1 |
| Model 2 | ||||
| Codominant contrast of DNMT1 rs2228611 | ||||
| GG | Reference | 1 | 0 | |
| AG | 1.05 | 2.87 (1.11-7.44) | 0.031 | 1 |
| AA | 1.34 | 3.82 (1.44-10.12) | 0.007 | 1 |
| Model 3 | ||||
| Recessive contrast of DNMT1 rs2228611 | ||||
| GG | Reference | 1 | 0 | |
| AA+AG | 1.16 | 3.21 (1.28-8.06) | 0.013 | 1 |
| Model 4 | ||||
| Mitochondrial haplogroup | ||||
| H | Reference | 1 | 0 | |
| Non-H | 0.77 | 2.16 (1.18-3.94) | 0.013 | 1 |
| Codominant contrast of DNMT1 rs2228611 | ||||
| GG | Reference | 1 | 0 | |
| AG | 1.05 | 2.86 (1.10-7.41) | 0.0031 | 1 |
| AA | 1.41 | 4.10 (1.54-10.88) | 0.005 | 2 |
| Model 5 | ||||
| Mitochondrial haplogroup | ||||
| H | Reference | 1 | 0 | |
| Non-H | 0.74 | 2.09 (1.15-3.80) | 0.017 | 1 |
| Recessive contrast of DNMT1 rs2228611 | ||||
| GG | Reference | 1 | 0 | |
| AA+AG | 1.19 | 3.29 (1.31-8.24) | 0.011 | 2 |
HR, hazard ratio; CI, confidence interval.