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. 2017 Apr 20;12(4):e0174767. doi: 10.1371/journal.pone.0174767

Table 1. Virological success (<400 copies/ml) at 12 months–on-treatment analysis.

Univariate Multivariate
analysis analysis
Variables Categories N Rate (95% CI) (p) Full model (p) Reduced model (p)
Study design Cohort 35 85.1 [83.2–87.8] Ref
Trial 17 86.1 [82.3–89.8] 0.90
Cross sectional 12 85.1 [81.3–88.9] 0.99
Beginning of enrolment ≤2005 34 84.4 [81.5–87.4] Ref
≥2006 30 86.3 [83.8–88.8] 0.36
End of enrolment ≤2005 11 85.6 [82.2–88.9] Ref
2006–2009 45 84.5 [82.2–86.9] 0.92
≥2010 7 89.6 [84.9–94.3] 0.46
Region Western Africa 16 81.5 [77.4–85.5] 0.11
Eastern Africa 25 87.3 [84.8–89.8] Ref
Central Africa 3 85.3 [78.2–92.4] 0.99
Southern Africa 16 86.6 [84.1–89.1] 0.99
Several region 2 76.2 [0.48–1.00] 0.18
Type of site Public sector 51 86.4 [84.5–88.3] Ref Ref Ref
Other 10 80.2 [73.2–87.3] 0.04 0.76 0.04
Number of sites 1 35 85.1 [81.9–88.3] Ref
≥2 20 85.9 [83.4–88.5] 0.76
Decentralised setting No 39 83.9 [80.8–86.9] Ref Ref
Yes 15 89.6 [85.7–93.5] 0.04 0.35
Both 7 82.4 [78.4–86.5] 0.79 0.30
Population selected General 44 85.9 [84.3–87.5] Ref Ref
General, with FU >6 months 7 77.5 [68.9–86.1] 0.01 0.43
Specific 7 89.0 [86.5–91.5] 0.44 0.61
VL monitoring before evaluation No 31 85.5 [82.1–88.8] Ref
Yes 33 85.2 [82.7–87.6] 0.86
Tracking of LTFU patients No 49 85.4 [83.0–87.9] Ref
Yes 15 85.0 [81.1–8.8] 0.85
Median age at ART initiation (years) ≤36 32 84.7 [82.4–87.0] Ref
>36 26 85.8 [81.4–90.2] 0.60
Proportion of women ≤65 34 86.8 [83.7–89.9] Ref
>65 30 83.7 [81.3–86.1} 0.14
Proportion of patients in WHO stage 3–4 ≤69 25 84.4 [82.0–86.8] Ref
>69 18 87.9 [85.3–90.6] 0.23
Median CD4 at ART initiation (cells/mm3) ≤135 30 85.9 [84.1–87.7] Ref
>135 27 84.4 [79.7–89.1] 0.84
Median VL at ART initiation (log copies/mL) ≤5.2 14 81.6 [77.3–85.8] Ref
>5.2 22 87.5 [84.8–90.1] 0.09
Proportion of EFV exposed patients ≤40 22 82.0 [77.2–86.9] Ref Ref
>40 20 87.4 [84.8–90.0] 0.04 0.99
Proportion of NVP exposed patients ≤60 23 85.2 [81.4–89.0] Ref
>60 19 83.1 [79.9–86.4] 0.41