Controls (normoxia group, No/No), after prenatal hypoxia and postnatal normoxia (Hypo/No group), after prenatal normoxia and postnatal hyperoxia ((No/Hyper group) and after prenatal hypoxia and postnatal hyperoxia (Hypo/Hyper group). Mean ± SD, *p<0.05, **p<0.01, ***p<0.001 compared to controls. a) The volume density of AEII showed a more or less pronounced variance in all groups. b) The volume weighted mean volume of AEII showed the significantly highest values compared to controls in the double hit model. c) Volume densities of Lb show comparable values in the one hit models, but significantly lower values in the Hypo/Hyper group. d) The volume weighted mean volume of Lb is comparable with control values in the Hypo/No and in the No/Hyper group. Significantly lower values were found in the double hit group.