Table 1.

Summary of T-type channel dependent synaptic plasticity.

Brain area	Synapse	Nature of synapse	Type of plasticity	Evidence of T currents	Other partners	Ref.
Thalamus	TC->NRT	Glut	LTP postsynaptic	Cav3.3 KO Voltage dependence	NMDAR (GluN2B)	72
	NRT -> TC VB	GABA	LTD postsynaptic	TTA-P2	mGluR1 GABAAR CamK	45
	NRT -> TC PO	GABA	LTP presynaptic	Voltage dependence	L type Ca2+ current NO Guanylate cyclase	46
Cortex	White matter -> layer II/III (cat)	Glut	LTP	Voltage dependence		16
	Layer IV-> layer II/III (rat)		? LTP ?	Ni2+ Voltage dependence Ni2+, Mibefradil, Kurtoxin, Efonidipine		82
	Pairs of layer V pyramidal neurons	Glut	LTP postsynaptic	Ni2+	NMDA R Backpropagating APs	36
	layer IV -> layer II/III	Glut	LTD presynaptic	Voltage dependence Ni2+	mGluR5 IP3R-dependent stores L type Ca2+ current Presynaptic NMDAR CB1R	74
	layer II/III -> layer V pyramidal neurons	Glut	LTD ?	Ni2+	Group I/II mGluR Backpropagating APs	38
	layer II/III -> layer II/III pyramidal neurons	Glut	LTD presynaptic	Ni2+	Group I mGluR PLC-activation L type Ca2+ current CB1R	44
Hippocampus	Schaffer collaterals -> CA1	Glut	LTP ?	Ni2+		55
	Schaffer collaterals -> CA1	Glut	LTP ?	Ni2+	NMDAR P type Ca2+ current	19
	-> CA1	Glut	LTP ?	Ni2+	NMDAR L type Ca2+ current Backpropagating APs	39
	Schaffer collaterals -> CA1	Glut	LTD presynaptic	Voltage dependence Ni2+	mGluR5 PKC	17
	Medial perforant pathway -> dentate granule cells	Glut	LTP ?	Voltage dependence Ni2+	Group I/II mGluR	18
	Stratum radiatum ->CA1	Glut	LTP ?	Cav3.2 KO mibefradil		92
Cerebellum	Parallel fibers -> Purkinje cells	Glut	LTP postsynaptic	Cav3.1 KO TTA-P2		77
	Mossy fibers ->cerebellar nuclear neurons	Glut	LTP ?	Voltage dependence	NMDAR (NR2D)	93
	Purkinje cells -> cerebellar nuclear neurons	GABA	LTD LTP ?	Voltage dependence Voltage dependence	– Action potentials	41
Basal ganglia	Globus pallidus -> subthalamic nucleus	GABA	LTP ?	mibefradil	L type Ca2+ current	94
Spinal cord	C fibers -> Lamina I neurons	Glut	LTP ?	Ni2+	Neurokinin1R Action potentials NMDAR	73