Table 4. Odds ratio (OR) and 95% confidence interval (CI) of clinical status and WWOX rs12918952 genotypic frequencies in 252 male HCC patients.
| Variable | Genotypic frequencies | |||
|---|---|---|---|---|
| GG (N = 224) | GA+AA (N = 28) | OR (95% CI) | p value | |
| Clinical Stage | ||||
| Stage I/II | 139 (62.1%) | 22 (78.6%) | 1.00 | p = 0.086 |
| Stage III/IV | 85 (37.9%) | 6 (21.4%) | 0.446 (0.174–1.144) | |
| Tumor size | ||||
| ≦ T2 | 140 (62.5%) | 22 (78.6%) | 1.00 | p = 0.094 |
| > T2 | 84 (37.5%) | 6 (21.4%) | 0.455 (0.177–1.166) | |
| Lymph node metastasis | ||||
| No | 115 (96.0%) | 27 (96.4%) | 1.00 | p = 0.909 |
| Yes | 9 (4.0%) | 1 (3.6%) | 0.885 (0.108–7.257) | |
| Distant metastasis | ||||
| No | 211 (94.2%) | 27 (96.4%) | 1.00 | p = 0.627 |
| Yes | 13 (5.8%) | 1 (3.6%) | 0.601 (0.076–4.778) | |
| Vascular invasion | ||||
| No | 190 (84.8%) | 19 (67.9%) | 1.00 | p = 0.024* |
| Yes | 34 (15.2%) | 9 (32.1%) | 2.647 (1.106–6.338) | |
| Child-Pugh grade | ||||
| A | 174 (77.7%) | 21 (75.0%) | 1.00 | p = 0.749 |
| B or C | 50 (22.3%) | 7 (25.0%) | 1.160 (0.466–2.886) | |
| HBsAg | ||||
| Negative | 120 (53.6%) | 16 (57.1%) | 1.00 | p = 0.721 |
| Positive | 104 (46.4%) | 12 (42.9%) | 0.865 (0.391–1.913) | |
| Anti-HCV | ||||
| Negative | 127 (56.7%) | 15 (53.6%) | 1.00 | p = 0.753 |
| Positive | 97 (43.3%) | 13 (46.4%) | 1.135 (0.516–2.496) | |
| Liver cirrhosis | ||||
| Negative | 47 (21.0%) | 4 (14.3%) | 1.00 | p = 0.406 |
| Positive | 177 (79.0%) | 24 (85.7%) | 1.593 (0.527–4.816) | |
The ORs with analyzed by their 95% CIs were estimated by logistic regression models.
> T2: multiple tumor more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s)
* p value < 0.05 as statistically significant.