Table 1. Description of the main clinical and demographic data.
| Variables | Number of cases (n = 183) |
|---|---|
| Gender | |
| Male | 115 (62.8%) |
| Race | |
| Caucasian | 162 (88.5%) |
| Age (years) | 65 (55–76) |
| Patient classification | |
| Medical | 132 (72.1%) |
| Surgical | 51 (27.9%) |
| Reason for ICU admission | |
| Infection | 101 (57.0%) |
| Cardiac failure | 12 (6.5%) |
| Liver failure | 12 (6.5%) |
| Hypovolemic/bleeding shock | 2 (1.1%) |
| Other medical causes | 5 (2.7%) |
| Solid organ transplantation | 20 (10.9%) |
| (Liver transplantation) | 15 (8.2%) |
| Elective or emergency surgery | 31 (16.0%) |
| Comorbidities | |
| Diabetes mellitus | 44 (24.0%) |
| Hypertension | 60 (32.8%) |
| Cardiovascular disease | 72 (39.3%) |
| Chronic obstructive pulmonary disease and other pulmonary diseases | 23 (12.6%) |
| Solid organ neoplasia | 28 (15.3%) |
| Hematologic malignancy or BMT | 36 (19.6%) |
| Cirrhosis | 38 (20.7%) |
| Liver transplantation | 33 (18.0%) |
| Causes of AKI | |
| Sepsis | 96 (52.5%) |
| Cardio renal syndrome | 15 (8.2%) |
| Hepatorenal syndrome | 16 (8.7%) |
| Solid organ transplantation | 20 (10.9%) |
| Trauma and surgery | 21 (11.5%) |
| Other causes | 15 (8.2%) |
| Classification of AKI at beginning of CVVHDF | |
| KDIGO 3 | 120 (65.6%) |
| KDIGO 2 | 54 (29.5%) |
| KDIGO 1 | 9 (4.9%) |
| Baseline creatinine in mg/dL | 1.00 (0.70–1.51) |
| Baseline eGFR in mL/min/1.73 m2 | 72 (40–102) |
| Vasopressors at beginning of CVVHDF | 152 (83.0%) |
| Mechanical ventilation at beginning of CVVHDF | 145 (79.2%) |
| Sedation at beginning of CVVHDF | 136 (74.3%) |
| Accompanying oliguria at beginning of CVVHDF | 114 (62.3%) |
| SAPS 3 score at ICU admission | 61 (50–74) |
| Predicted mortality by SAPS 3 (%) | 37.7 (20.1–64.0) |
| SOFA score at ICU admission | 10 (7–12) |
| Total SOFA score on the first day of CVVHDF (n = 183) | 13 (11–16) |
| Total SOFA score on the third day of CVVHDF (n = 173) | 13 (11–15) |
| Total SOFA score on the seventh day of CVVHDF (n = 98) | 14 (11–16) |
| Length of stay in hospital (days) | 35 (21–67) |
| Length of stay in ICU (days) | 14 (7–22) |
| Mortality up to 90 days | 105 (57.4%) |
ICU, intensive care unit; BMT, bone marrow transplantation; AKI, acute kidney injury; CVVHDF, continuous venovenous hemodiafiltration; eGFR, estimated glomerular filtration rate; KDIGO, Kidney Disease Improving Global Outcomes classification of acute kidney injury; SAPS 3, Simplified Acute Physiology Score 3; SOFA, Sequential Organ Failure Assessment score. Categorical variables described by absolute value (percentage) and numeric variables described by median (IQR).