Table 1. Baseline characteristics of the patients.
| Before IPW | After IPW | |||||
|---|---|---|---|---|---|---|
| NAG | AG | p-value | NAG | AG | p-value | |
| N | 39 | 54 | 92 | 93 | ||
| Age, mean ± SD (years) | 60.9 ± 8.7 | 60.5 ± 6.5 | 0.808 | 61.0 ± 8.0 | 60.6 ± 6.6 | 0.726 |
| Male, N (%) | 11 (28.2) | 22 (40.7) | 0.274 | 35 (38.0) | 33 (35.5) | 0.878 |
| Hypertension, N (%) | 6 (15.4) | 21 (38.9) | 0.020 | 25 (27.2) | 27 (29.0) | 0.870 |
| Diabetes mellitus, N (%) | 3 (7.7) | 9 (16.7) | 0.231 | 8 (8.7) | 12 (12.9) | 0.479 |
| Hyperlipidemia, N (%) | 2 (5.1) | 6 (11.1) | 0.461 | 12 (13.0) | 8 (8.6) | 0.476 |
| Smoking, N (%) | 2 (5.1) | 3 (5.6) | 1.000 | 4 (4.3) | 5 (5.4) | 1.000 |
| Baseline WMH | ||||||
| Absolute volume, Median (IQR) (mm3) |
||||||
| Total | 1602.45 (619.52–2375.58) |
2169.64 (1165.09–3874.43) |
0.026 | 1866.94 (721.52–3020.09) |
1892.68 (1114.92–3324.54) |
0.783 |
| Deep | 256.36 (146.62–610.88) |
421.04 (196.54–1679.78) |
0.035 | 400.88 (171.34–987.40) |
359.81 (158.08–1008.88) |
0.611 |
| Periventricular | 1229.95 (420.27–1865.31) |
1451.97 (880.93–2626.17) |
0.053 | 1402.70 (586.17–2542.06) |
1228.48 (843.83–1915.21) |
0.952 |
| *Normalized volume, Median (IQR) |
||||||
| Total | 0.129 (0.464–0.182) |
0.158 (0.089–0.275) |
0.036 | 0.136 (0.055–0.245) |
0.124 (0.082–0.237) |
0.915 |
| Deep | 0.020 (0.011–0.051) |
0.031 (0.016–0.133) |
0.041 | 0.029 (0.013–0.071) |
0.026 (0.011–0.070) |
0.680 |
| Periventricular | 0.098 (0.031–0.136) |
0.107 (0.064–0.186) |
0.096 | 0.109 (0.043–0.210) |
0.094 (0.058–0.153) |
0.743 |
|
†Time interval, mean ± SD (days) |
1913.6 ± 181.8 | 1903.4 ± 158.6 | 0.776 | 1912.6 ± 180.44 | 1903.8 ± 157.9 | 0.725 |
IPW = inverse probability weighting; NAG = non-antiplatelet group; AG = antiplatelet group.
N = number; SD = standard deviation; WMH = white matter hyperintensity; IQR = interquartile range.
* Normalized volume of WMH = [total volume of WMH/intracranial volume] × 100.
† Time interval between the baseline and follow-up MRI scans.