Table 2. Odds ratio (OR) and 95% confidence interval (CI) of oral cancer associated with WISP1 genotypic frequencies.
| Variable | Controls (N = 1200) n (%) | Patients (N = 900) n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs62514004 | ||||
| AA | 926 (77.2%) | 707 (78.6%) | 1.00 | 1.00 |
| AG | 253 (21.1%) | 180 (20.0%) | 0.932 (0.752–1.155) | 0.956 (0.726–1.259) |
| GG | 21 (1.7%) | 13 (1.4%) | 0.811 (0.403–1.630) | 0.682 (0.276–1.687) |
| AG+GG | 274 (22.8%) | 193 (21.4%) | 0.923 (0.749–1.137) | 0.943 (0.714–1.211) |
| rs16893344 | ||||
| CC | 877 (73.1%) | 662 (73.6%) | 1.00 | 1.00 |
| CT | 298 (24.8%) | 222 (24.7%) | 0.987 (0.807–1.207) | 0.956 (0.737–1.239) |
| TT | 25 (2.1%) | 16 (1.8%) | 0.848 (0.449–1.601) | 0.795 (0.349–1.812) |
| CT+TT | 323 (26.9%) | 238 (26.4%) | 0.976 (0.803–1.187) | 0.943 (0.733–1.214) |
| rs2977530 | ||||
| AA | 337 (28.1%) | 263 (29.2%) | 1.00 | 1.00 |
| AG | 573 (47.8%) | 435 (48.3%) | 0.973 (0.793–1.193) | 0.840 (0.645–1.093) |
| GG | 290 (24.1%) | 202 (22.5%) | 0.893 (0.701–1.136) | 0.810 (0.592–1.108) |
| AG+GG | 863 (71.9%) | 637 (70.8%) | 0.946 (0.781–1.145) | 0.830 (0.648–1.063) |
| rs2977537 | ||||
| GG | 330 (27.5%) | 233 (25.9%) | 1.00 | 1.00 |
| GA | 581 (48.4%) | 435 (48.3%) | 1.060 (0.861–1.307) | 1.033 (0.789–1.353) |
| AA | 289 (24.1%) | 232 (25.8%) | 1.137 (0.894–1.447) | 1.191 (0.873–1.625) |
| GA+AA | 870 (72.5%) | 667 (74.1%) | 1.086 (0.893–1.321) | 1.085 (0.842–1.397) |
| rs2929970 | ||||
| AA | 439 (36.6%) | 302 (33.6%) | 1.00 | 1.00 |
| AG | 583 (48.6%) | 443 (49.2%) | 1.105 (0.912–1.338) | 1.248 (0.973–1.600) |
| GG | 178 (14.8%) | 155 (17.2%) | 1.266 (0.976–1.642) | 1.463 (1.045–2.048)* |
| AG+GG | 761 (63.4%) | 598 (66.4%) | 1.142 (0.953–1.370) | 1.298 (1.026–1.642)* |
| rs2929973 | ||||
| TT | 503 (41.9%) | 395 (43.9%) | 1.00 | 1.00 |
| TG | 560 (46.7%) | 391 (43.4%) | 0.889 (0.739–1.069) | 0.976 (0.769–1.238) |
| GG | 137 (11.4%) | 114 (12.7%) | 1.060 (0.800–1.404) | 1.133 (0.789–1.627) |
| TG+GG | 697 (58.1%) | 505 (56.1%) | 0.923 (0.775–1.099) | 1.007 (0.804–1.262) |
The odds ratio (OR) with their 95% confidence intervals were estimated by logistic regression models.
The adjusted odds ratio (AOR) with their 95% confidence intervals were estimated by multiple logistic regression models after controlling for betel nut chewing, alcohol and tobacco consumption.