Table 2. Hazard Ratios (HR) and Confidence Intervals (CI) for the main effects of genetic risk score (GRS) and stress on incidence of coronary artery disease (CAD), fatal myocardial infarction (MI), non-fatal MI, and cardiovascular death.
| GRS Quartiles | Stress | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P for trend | Low | Intermediate | High | P for trend | |
| CAD | |||||||||
| No. (Events) | 4640 (370) | 4640 (462) | 4641 (507) | 4638 (599) | 7234 (817) | 8227 (864) | 3098 (257) | ||
| Minimal model* HR (95% CI) |
Reference |
1.27
(1.11–1.46) |
1.44
(1.26–1.65) |
1.74
(1.53–1.98) |
Reference | 1.08 (0.98–1.19) |
1.11 (0.96–1.28) |
||
| P value | - | <0.001 | <0.001 | <0.001 | - | n.s. | n.s. | ||
| Multivariable model† HR (95% CI) |
Reference |
1.24 (1.08–1.42) |
1.43 (1.25–1.64) |
1.72
(1.51–1.96) |
<0.001 | Reference | 0.99 (0.90–1.09) |
0.99 (0.86–1.14) |
n.s. |
| P value | - | 0.002 | <0.001 | <0.001 | - | n.s. | n.s. | ||
| Fatal MI | |||||||||
| No. (Events) | 4640 (81) | 4640 (113) | 4641 (116) | 4638 (126) | 7234 (173) | 8227 (203) | 3098 (60) | ||
| Minimal model* HR (95% CI) |
Reference |
1.42 (1.06–1.88) |
1.51 (1.14–2.01) |
1.69 (1.28–2.24) |
Reference |
1.24 (1.01–1.52) |
1.43 (1.06–1.93) |
||
| P value | - | 0.017 | 0.004 | <0.001 | - | 0.042 | 0.019 | ||
| Multivariable model† HR (95% CI) |
Reference |
1.35 (1.02–1.80) |
1.49 (1.12–1.98) |
1.62 (1.23–2.15) |
<0.001 | Reference | 1.09 (0.88–1.34) |
1.22 (0.90–1.65) |
n.s. |
| P value | - | 0.039 | 0.006 | <0.001 | - | n.s. | n.s. | ||
| Non-fatal MI | |||||||||
| No. (Events) | 4640 (227) | 4640 (253) | 4641 (291) | 4638 (337) | 7234 (470) | 8227 (490) | 3098 (148) | ||
| Minimal model* HR (95% CI) |
Reference | 1.13 (0.94–1.35) |
1.34 (1.12–1.59) |
1.57 (1.33–1.86) |
Reference | 1.05 (0.92–1.19) |
1.07 (0.89–1.30) |
||
| P value | - | n.s. | 0.001 | <0.001 | - | n.s. | n.s. | ||
| Multivariable model† HR (95% CI) |
Reference | 1.09 (0.91–1.31) |
1.34 (1.12–1.59) |
1.55 (1.31–1.84) |
<0.001 | Reference | 0.96 (0.85–1.09) |
0.97 (0.80–1.17) |
n.s. |
| P value | - | n.s. | 0.001 | <0.001 | - | n.s. | n.s. | ||
| Cardiovascular death | |||||||||
| No. (Events) | 4640 (239) | 4640 (246) | 4641 (290) | 4638 (296) | 7234 (448) | 8227 (493) | 3098 (130) | ||
| Minimal model* HR (95% CI) |
Reference | 1.03 (0.86–1.23) |
1.27 (1.07–1.51) |
1.32 (1.12–1.57) |
Reference | 1.12 (0.99–1.28) |
1.21 (1.00–1.48) |
||
| P value | - | n.s. | 0.006 | 0.001 | - | n.s. | n.s. | ||
| Multivariable model† HR (95% CI) |
Reference | 1.00 (0.83–1.19) |
1.26 (1.06–1.50) |
1.29 (1.08–1.53) |
<0.001 | Reference | 1.02 (0.89–1.16) |
1.06 (0.87–1.30) |
n.s. |
| P value | - | n.s. | 0.009 | 0.004 | - | n.s. | n.s. | ||
CAD = Coronary artery disease; CI = Confidence Interval; GRS = Genetic risk score; HR = Hazard Ratio; MI = Myocardial infarction; n.s. = non-significant.
*Minimal models are adjusted for gender and age
†Multivariable models are adjusted for gender, age, education, socioeconomic index, smoking, drinking, prevalent diabetes mellitus, Body Mass Index, hypertension, and use of lipid lowering medication