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. 2016 May 26;8:113–122. doi: 10.2147/EB.S94451

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© 2016 Trinh et al. This work is published and licensed by Dove Medical Press Limited

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Ischemic injury on retinal micro-blood vessel results in loss of pericytes and endothelial cells and vaso-occlusion.

Notes: MSCs and ASCs differentiate into pericytes. Cell-surface receptors on intravitreally injected iPS-ECFCs or ECFCs interact with paracrine-released factors from CD34⁺ cells to differentiate into endothelial cells.

Abbreviations: MSCs, mesenchymal stem cells; RBC, red blood cells; ASCs, adipose-derived stem cells; iPS-ECFCs, induced pluripotent stem endothelial colony-forming cells.