Table 2.
Top 5 Gene Ontology Terms for Hyper-DhMRs.
| Gene Ontology Term | FDR P-value | **Gene Symbols |
|---|---|---|
| *Generation of neurons | 0.00000000509 | Mycbp2, Foxp1, Braf, Arhgef28, Ank3, Rnd2, Arsb, Atoh1, Prdm1, Bmp2, Bmpr1a, Runx2, Cdh11, Epha3, Epha4, Etv1, Gdnf, Gfra1, Lpar1, Hgf, Hhip, Ifrd1, Il2, Itgb1, Kif5b, Lama2, Man2a1, Mllt4, Trpm1, Map2, Ncam1, Ctnnd2, Ntrk3, Nr4a2, Enpp2, Prkg1, Prox1, Ptprd, Ptprm, Rheb, Robo1, Sema6a, Slit2, Sox14, Sox5, Cpeb3, Stxbp1, Arfgef1, Tcf4, Zeb1, Zfp521, Psd3, Tenm2, Tenm3, Kif20b, Prickle2, Rgma, Lsamp, Negr1, Slitrk3, Rgs6, Magi2, Park2, Corin, Golga4, Dfna5, Rapgef4, Gsk3b, Cdon, Sall1, Dleu2, Hmg20a, Zswim6, Agtpbp1, Rere, Tmem106b, Prmt3, Fryl, Ispd, Sdccag8, Fgf20, Sirt1 |
| *Nervous system development | 0.0000000186 | Mycbp2, Adgrb1, Foxp1, Braf, Arhgef28, Ank3, Rnd2, Arsb, Atoh1, Prdm1, Bmp2, Bmpr1a, Runx2, Cdh11, Epha3, Epha4, Etv1, Gdnf, Gfra1, Lpar1, Grik1, Hgf, Hhip, Hspg2, Ifrd1, Il2, Itgb1, Kif5b, Lama2, Man2a1, Mllt4, Trpm1, Map2, Ncam1, Nfia, Ctnnd2, Nrxn1, Nrxn3, Musk, Ntrk3, Nr4a2, Otx1, P2ry1, Enpp2, Prkg1, Prox1, Ptprd, Ptprm, Rheb, Robo1, Nptn, Sema6a, Slit2, Sox14, Sox5, Cpeb3, Stxbp1, Arfgef1, Tcf4, Zeb1, Alx1, Ttn, Zfp521, Psd3, Tenm2, Tenm3, Kif20b, Prickle2, Rgma, Mcph1, Rpgrip1l, Rbfox1, Lsamp, Negr1, Slitrk3, Rgs6, Magi2, Park2, Corin, Golga4, Dfna5, Cadm1, Rapgef4, Gsk3b, Cdon, Sall1, Dleu2, Hmg20a, Zswim6, Agtpbp1, Rere, Dpf3, Tmem106b, Prmt3, Fryl, Kif1bp, Ispd, Sdccag8, Hdac9, Fgf20, Sirt1 |
| *Neurogenesis | 0.0000000186 | Braf, Agtpbp1, Ank3, Arfgef1, Arhgef28, Arsb, Atoh1, Bmp2, Bmpr1a, Cdh11, Cdon, Corin, Cpeb3, Ctnnd2, Dfna5, Dleu2, Enpp2, Epha3, Epha4, Etv1, Fgf20, Foxp1, Fryl, Gdnf, Gfra1, Golga4, Gsk3b, Hgf, Hhip, Hmg20a, Ifrd1, Il2, Ispd, Itgb1, Kif20b, Kif5b, Lama2, Lpar1, Lsamp, Magi2, Man2a1, Map2, Mllt4, Mycbp2, Ncam1, Negr1, Nr4a2, Ntrk3, P2ry1, Park2, Prdm1, Prickle2, Prkg1, Prmt3, Prox1, Psd3, Ptprd, Ptprm, Rapgef4, Rere, Rgma, Rgs6, Rheb, Rnd2, Robo1, Runx2, Sall1, Sdccag8, Sema6a, Sirt1, Slit2, Slitrk3, Sox14, Sox5, Stxbp1, Tcf4, Tenm2, Tenm3, Tmem106b, Trpm1, Zeb1, Zfp521 |
| Cell Development | 0.0000000366 | Camk2d, Abi1, Agfg1, Akap6, Alx1, Ank3, Arfgef1, Arhgef28, Arid4a, Arsb, Atoh1, Bin3, Bmp2, Bmpr1a, Braf, Cdh11, Cdon, Cnot2, Col11a1, Cpeb3, Ctnnd2, Dleu2, Enpp2, Epha3, Epha4, Etv1, Fermt2, Foxp1, Fryl, Gdnf, Gfra1, Golga4, Gsk3b, Hdac9, Hgf, Hmg20a, Hspa2, Ifrd1, Il2, Impad1, Ispd, Itga4, Itgb1, Kif20b, Kif5b, Klf5, Lama2, Lims1, Lpar1, Lsamp, Magi2, Maml1, Man2a1, Map2, Megf10, Mllt4, Mycbp2, Ncam1, Negr1, Nr4a2, Ntrk3, Park2, Prdm1, Prickle2, Prkg1, Prmt3, Prox1, Ptprd, Ptprm, Rap1b, Rapgef4, Rdx, Rere, Rgma, Rgs6, Rheb, Rnd2, Robo1, Runx2, S1pr3, Sall1, Sema6a, Sirt1, Slc8a1, Slit2, Slitrk3, Smyd3, Sox14, Sox5, Stxbp1, Tcf4, Tenm2, Tenm3, Tmem106b, Trpm1, Trps1, Ttn, Zeb1, Zfp42, Zswim6 |
| *Neuron differentiation | 0.0000000366 | Mycbp2, Foxp1, Braf, Arhgef28, Ank3, Rnd2, Arsb, Atoh1, Prdm1, Bmp2, Runx2, Cdh11, Epha3, Epha4, Etv1, Gdnf, Gfra1, Lpar1, Hgf, Ifrd1, Il2, Itgb1, Kif5b, Lama2, Trpm1, Map2, Ncam1, Ctnnd2, Ntrk3, Nr4a2, Prkg1, Prox1, Ptprd, Ptprm, Robo1, Sema6a, Slit2, Sox5, Cpeb3, Stxbp1, Arfgef1, Tcf4, Zeb1, Zfp521, Psd3, Tenm2, Tenm3, Kif20b, Prickle2, Rgma, Negr1, Slitrk3, Rgs6, Magi2, Park2, Corin, Golga4, Dfna5, Rapgef4, Gsk3b, Cdon, Sall1, Dleu2, Hmg20a, Zswim6, Agtpbp1, Rere, Tmem106b, Prmt3, Fryl, Ispd, Fgf20, Sirt1 |
*
Indicates neuronal-related pathway as previously determined by Geigman et al., 2010
**
Bolded gene symbols indicate known stress-related genes from the GeneCards database.