Figure 3.

Pearson correlation coefficients (r; axis Y) between clinical phenotype (axis X) and (A) the 30 top ranking DNA methylated sites inversely or directly associated with NASH or (B) CpG methylated sites that mapped to the genes in the KEGG enriched pathways negatively associated with NASH. Size of the circles indicates statistical significance (P-value). Filled circles: P > 0.05; empty circles: P < 0.05 in panel A ranging from P = 0.049 to P = 7.1 × 10⁻⁶ and in panel B ranging from P = 0.049 to P = 4.0 × 10⁻⁶, where a larger circle indicates a higher statistical significance. C: cholesterol; TG: triglycerides; Glucose: fasting glucose; Insulin: fasting insulin.