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. Author manuscript; available in PMC: 2018 Mar 27.
Published in final edited form as: Dev Cell. 2017 Mar 27;40(6):583–594.e6. doi: 10.1016/j.devcel.2017.02.020

Figure 2. Mdivi-1 does not alter mitochondrial size in neuronal processes.

Figure 2

(A) Representative immunofluorescence of Tom20 (red) and Drp1 (green) in neurons following treatment with DMSO vehicle (CTRL) or mdivi-1 (75 μM) for 1 or 5 hr (scale bars, 10 μm). Extrasomal Tom20 and Drp1 fluorescence is primarily localized to a meshwork of neuronal processes. (B) Frequency of binned mitochondrial areas for the treatments described in (A). (C) Pearson’s coefficient for Drp1 co-localized with mitochondrial Tom20 in neurons treated with CTRL or 75 μM mdivi-1. Results are mean ± SD, where ~800–1000 mitochondria were counted per treatment group per experiment, and 3 separate experiments were conducted. See also Figure S2.