Table 3.
Adjusted analyses for primary and secondary outcomes in the propensity-matched cohort in those with INR ≥ 1.5.
| Outcomea | Prophylactic plasma (n=618) | No therapy (n=618) | P Value* | OR (95% CI)* |
|---|---|---|---|---|
| RBC transfusion within 24 hours | 176 (28.5) | 94 (15.2) | < 0.001 | 3.4 (2.4, 4.8) |
| Mortality | 120 (19.4) | 118 (19.1) | 0.400 | 1.1 (0.8, 1.5) |
| Outcomea | Prophylactic plasma (n=618) | No therapy (n=618) | P Value* | Estimated % increase (95% CI)* |
| ICU free days | 25.8 (22.9, 27.1) | 24.9 (21.7, 26.5) | < 0.001 | 2.3 (1.8, 2.8) |
| Hospital free days | 18.9 (10.7, 22.7) | 20.6 (15.4, 23.6) | < 0.001 | −13.0 (−12.5, −13.5) |
a
Numbers are n (%) for categorical outcomes and median (Q1,Q3) for continuous outcomes.
†
Estimates and p-values are from logistic regression for categorical outcomes and negative binomial regression for length of stay. Model was adjusted using INR and therapeutic heparin. Odds ratios > 1 imply increased odds for the outcome in those receiving plasma. Estimated % increase < 0 imply fewer free days in those receiving plasma.
CI = confidence interval; RBC = red blood cell transfusion; ICU = intensive care unit.