Table 2.
| Target Gene | Reference | Sex Difference/Hormone regulation | Reference |
|---|---|---|---|
| CASP3 (Caspase-3) | (Floyd et al., 2014) | Neonatal expression in the hypothalamus Functional difference: Females are more sensitive to caspase-mediated cell death |
(Tsukahara et al., 2006, Tsukahara, 2009) (Liu et al., 2009, Liu et al., 2011, Sharma et al., 2011) |
| Caspase-9 | (Floyd et al., 2014) | Functional difference: Females are more sensitive to caspase-mediated cell death | (Liu et al., 2011) |
| BIM Bcl2-like protein 11 |
(Floyd et al., 2014) | Neonatal expression in the hypothalamus | (Tsukahara et al., 2006, Tsukahara, 2009) |
| NOTCH1 | (Song et al., 2015) | Estrogen enhances NOTCH signaling in bone marrow-derived mesenchymal stem cells (BMSCs) Estrogen increases NOTCH1 processing in endothelial cells |
(Fan et al., 2014) (Caliceti et al., 2013) |
| CREB1 | (Li et al., 2016) | Associated with depression in men Elevated CREB1 RNA after high fat diet in females only |
(Utge et al., 2010) (Shannonhouse et al., 2015) |
| MALAT1 | (Wang et al., 2016) | Estradiol decreases MALAT1 RNA in MCF10 cells Increased MALAT1 RNA expression at male-specific temperature-dependent sex determination |
(Zhao et al., 2014) (Chojnowski and Braun, 2012) |