Table 1.

Primary Immunodeficiencies Affecting the Th17 Cell Pathway Linked to Susceptibility to Oral Mucosal Infection.

Oral manifestation	Gene affected by mutation	Clinical Syndrome (If described)	Reference
Chronic Mucocutaneous Candidiasis (CMC)	IL-17RA, IL-17RC IL-17F, ACT1		(Puel et al., 2011) (Boisson et al., 2013) (Ling et al., 2015)
	Loss-of -function STAT3	Autosomal dominant hyper IgE syndrome (AD-HIES)	(Freeman & Holland, 2009)
	Gain-of-function STAT1		(Liu et al., 2011)
	AIRE	Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy (APECED)	(Meloni et al., 2012)
	DOCK8	Autosomal recessive hyper IgE syndrome (AR-HIES)	(Zhang et al., 2009)
	DECTIN-1		(Ferwerda et al., 2009)
	CARD-9		(Glocker et al., 2009)
	IRF8		(Hambleton et al., 2011)
	STK4		(Abdollahpour et al., 2012)
	CD45, IL7RA, RAG1, RAG2, ADA, AK2 JAK3, ARTEMIS	Severe combined immunodeficiency (SCID)	(Buckley, 2004)