Fig. 4.

Minocycline rescues prion-infected hamsters from spongiform degeneration. (a) Representative hematoxylin and eosin stained pictures from different regions of brain for estimating vacuolation profile in different experimental groups. (b) Graphical presentation of the vacuolation profile in medulla, cerebellum, thalamus, and cortex from 5 animals analyzed in each set. Data represent the average ± SE of the extent of vacuolation. Data were analyzed by 2-way analysis of variance with Bonferroni’s post-test (***p < 0.001). ns = nonsignificant