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. 2016 Dec 12;14(2):417–428. doi: 10.1007/s13311-016-0501-z

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Pharmacokinetic properties of ACY-738 and ACY-775 in N2a cells. (a) Dose–response of trichostatin A (TSA), ACY-738, or ACY-775 on acetylation of α-tubulin was established in N2a cells and determined by Western blot. (b) Quantification of the ratio of acetylated α-tubulin to total tubulin levels on Western blot. Values were normalized to the effect of 2.5 μM (n = 3)