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Nalbuphine plasma levels. Nalbuphine plasma levels at 15 min (sham nalbuphine, n = 6), 4 h (sepsis nalbuphine, n = 6) and 24 h (sepsis nalbuphine, n = 4). Samples were obtained from independent animals without repeated blood sampling (one-way ANOVA p < 0.001). Post-hoc test revealed significantly higher plasma levels at 4 h (§: p = 0.002) and 24 h (£: p < 0.001) vs 15 min. There was no significant difference between 4 and 24 h
