Table 1.
Clinical characteristics of the patients
| Total “N”: 278 patients | SOFA < 8 N = 122 |
SOFA ≥ 8 N = 156 |
p value | |
|---|---|---|---|---|
| Characteristics | Cohort GRECIA/ABISS | 81/41 | 99/57 | n.s |
| Age (years) | 70.5 (18.0) | 67.50 (19.0) | n.s | |
| Sex (male) | 70 (57.4%) | 112 (71.8%) | 0.012 | |
| Comorbidities | Chronic cardiovascular disease | 15 (12.3%) | 21 (13.5%) | n.s |
| Chronic respiratory disease | 21 (17.2%) | 29 (18.6%) | n.s | |
| Chronic renal failure | 12 (9.80%) | 16 (10.3%) | n.s | |
| Chronic hepatic failure | 2 (1.6%) | 11 (7.1%) | 0.034 | |
| Diabetes mellitus | 23 (18.9%) | 24 (15.4%) | n.s | |
| Immunosuppression | 23 (18.9%) | 39 (25.0%) | n.s | |
| Severity and outcome | APACHE-II | 18.0 (7.0) | 23.0 (10.0) | 0.001 |
| Sepsis with cardiovascular dysfunction | 77 (63.1%) | 147 (94.2%) | 0.001 | |
| Mortality at the ICU | 18 (14.8%) | 47 (30.1%) | 0.003 | |
| Mortality at the hospital | 28 (23.0%) | 55 (35.3%) | 0.026 | |
| Source of infection | Respiratory | 47 (40.2%) | 59 (38.8%) | n.s |
| Abdominal | 38 (32.5%) | 44 (29.1%) | n.s | |
| Urinary tract | 14 (12.0%) | 21 (13.9%) | n.s | |
| Bacteremia–catheter | 3 (2.6%) | 11 (7.3%) | n.s | |
| Other | 15 (12.8%) | 15 (9.9%) | n.s | |
| Microbiologically confirmed infection | 57 (46.7%) | 92 (59.0%) | 0.047 | |
| Microbiology | Gram-negative bacteria | 28 (23%) | 55 (35.3%) | 0.029 |
| Gram-positive bacteria | 31 (25.4%) | 35 (22.4%) | n.s | |
| Fungemia | 6 (4.9%) | 3 (1.9%) | n.s | |
| Other | 4 (3.3%) | 4 (2.6%) | n.s | |
| Polimicrobian sepsis | 16 (13.1%) | 11 (7.1%) | n.s | |
| Laboratory parameters at diagnosis | White blood cells (cells/mm3) | 15.800 (9500) | 15.400 (15,080) | n.s |
| Platelets/µl | 210.000 (136,000) | 133.000 (142,500) | 0.001 | |
| Potassium (mEq/l) | 4.2 (0.8) | 4.3 (1.0) | n.s | |
| Sodium (mEq/l) | 138.0 (8.0) | 139.0 (9.0) | n.s | |
| Glycemia (mg/dl) | 167.0 (94.0) | 170.0 (87.0) | n.s | |
| Creatinine (mg/dl) | 1.2 (1.1) | 2.0 (1.7) | 0.001 | |
| Albumin (g/dl) | 2.3 (1.0) | 2.3 (0.8) | n.s | |
| IgG total (mg/dl) | 618.2 (516.0) | 528.7 (469.0) | n.s | |
| IgG1 (mg/dl) | 482.6 (370.5) | 446.71 (377.9) | n.s | |
| IgG2 (mg/dl) | 17.8 (28.2) | 15.0 (21.2) | n.s | |
| IgG3 (mg/dl) | 51.1 (76.0) | 49.8 (62.0) | n.s | |
| IgG4 (mg/dl) | 17.2 (46.5) | 16.3 (35.0) | n.s | |
| IgM (mg/dl) | 38.0 (37.4) | 36.40 (32.1) | n.s | |
| IgA (mg/dl) | 278.7 (343.0) | 273.3 (375.6) | n.s |
Continuous variables are shown as median (inter-quartile rank) and categorical variables as n (%)
n.s. not significant