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. 2017 Apr 21;8:211. doi: 10.3389/fphar.2017.00211

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Copyright © 2017 Cui, Wang, Chen, Lv, Zhang, Zhang, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The perturbed metabolites and metabolic pathways related to CPT-11 treatment as well as TCM (HQD, SS, BB, or SF decoctions) modification. Elevation (up arrows) and reduction (down arrows) of the levels of metabolites observed in rats are indicated. SS, single S. baicalensis; BB, baicalin and baicalein; SF, S. baicalensis free; T, CPT-11.