Table 7.

Assessment of BMD_t and BMDL_t derived from each approach against the three criteria for predicting apical PODs at the 5-, 14-, 28-, and 90-day time points

Approach	5 days	14 days	28 days	90 days	Sum	%
1	15	16	14	10	55	76
2	13	15	14	9	51	71
3	11	11	13	10	45	63
4	17	15	13	15	60	83
5	14	16	13	12	55	76
6	13	16	14	8	51	71
7	15	16	15	9	55	76
8	15	15	12	11	53	74
9	11	10	15	8	44	61
10	9	9	12	8	38	53
11	9	9	12	8	38	53

BMD_t values were assessed for predicting four apical endpoints (NOAEL, LOAEL, lowest BMD_a at matched time point of apical endpoints, lowest BMD_a overall of apical data); BMDL_t values were assessed for predicting two apical endpoint (NOAEL and LOAEL). Sum = (three criteria × four apical PODs × four time points = 48) + (three criteria × two apical PODs × four time points = 24) = 72. The top approaches that met the three criteria are highlighted in bold (there was a three-way tie for second place)