Table 1.
Significantly regulated genes involved in phase I and phase II metabolism and metabolism signaling
| Gene title | Gene symbol | Fold change | P value |
|---|---|---|---|
| Alcohol dehydrogenase 5 (Class III) | ADH5 | 1.6 | 0.037 |
| Aryl hydrocarbon receptor | AHR | −1.7 | 0.046 |
| Aldehyde dehydrogenase 1 family, member A1 | ALDH1A1 | 4.0 | 0.009 |
| Aldehyde dehydrogenase 3 family, member A2 | ALDH3A2 | 3.5 | 0.008 |
| Aldehyde dehydrogenase 8 family, member A1 | ALDH8A1 | 2.2 | 0.047 |
| Calcium/calmodulin-dependent protein kinase II beta | CAMK2B | −3.3 | 0.046 |
| Carboxylesterase 2 | CES2 | 2.4 | 0.043 |
| Cbp/P300-interacting transactivator, with Glu/Asp-Rich carboxy-terminal domain, 2 | CITED2 | 4.1 | 0.029 |
| Cytochrome P450, family 1, subfamily A, polypeptide 1 | CYP1A1 | 136.6 | 0.0002 |
| Cytochrome P450, family 1, subfamily A, polypeptide 2 | CYP1A2 | 11.1 | 0.019 |
| Cytochrome P450, family 1, subfamily B, polypeptide 1 | CYP1B1 | 14.1 | 0.006 |
| Cytochrome P450, family 24, subfamily a, polypeptide 1 | CYP24A1 | 30.2 | 0.0005 |
| Cytochrome P450, family 26, subfamily a, polypeptide 1 | CYP26A1 | 4.7 | 0.017 |
| Cytochrome P450, family 26, subfamily b, polypeptide 1 | CYP26B1 | 2.9 | 0.033 |
| Cytochrome P450, family 2, subfamily a, polypeptide 6 | CYP2A6 | 10.3 | 0.041 |
| Cytochrome P450, family 2, subfamily b, polypeptide 6 | CYP2B6 | 2.9 | 0.037 |
| Cytochrome P450, family 2, subfamily c, polypeptide 18 | CYP2C18 | 4.0 | 0.017 |
| Cytochrome P450, family 2, subfamily c, polypeptide 19 | CYP2C19 | 6.0 | 0.046 |
| Cytochrome P450, family 2, subfamily c, polypeptide 8 | CYP2C8 | 2.6 | 0.041 |
| Cytochrome P450, family 2, subfamily c, polypeptide 9 | CYP2C9 | 4.0 | 0.043 |
| Cytochrome P450, family 3, subfamily a, polypeptide 4 | CYP3A4 | 11.7 | 0.047 |
| Eukaryotic translation initiation factor 2-alpha kinase 3 | EIF2AK3 | −1.8 | 0.047 |
| Fas cell surface death receptor | FAS | 2.8 | 0.021 |
| Growth arrest and DNA-damage-inducible, beta | GADD45B | −11.0 | 0.011 |
| Glutathione S-transferase alpha 1 | GSTA1 | 20.4 | 0.044 |
| Glutathione S-transferase alpha 2 | GSTA2 | 30.9 | 0.019 |
| Glutathione S-transferase alpha 3 | GSTA3 | 1.8 | 0.035 |
| Glutathione S-transferase alpha 5 | GSTA5 | 8.9 | 0.047 |
| Glutathione S-transferase Mu 4 | GSTM4 | 2.0 | 0.029 |
| Glutathione S-transferase Omega 1 | GSTO1 | 3.6 | 0.017 |
| Microsomal glutathione S-transferase 1 | MGST1 | 4.1 | 0.014 |
| Microsomal glutathione S-transferase 3 | MGST3 | 1.8 | 0.034 |
| N-Acetyltransferase 8 | NAT8 | 8.2 | 0.008 |
| Nuclear receptor co-activator 7 | NCOA7 | −2.0 | 0.039 |
| N-Deacetylase/N-Sulfotransferase (heparan glucosaminyl) 2 | NDST2 | −1.9 | 0.035 |
| Nuclear factor I/X | NFIX | −2.3 | 0.047 |
| NAD(P)H dehydrogenase, quinone 1 | NQO1 | 10.4 | 0.0006 |
| Phosphoenolpyruvate carboxykinase 2 | PCK2 | 4.3 | 0.024 |
| Peroxisome proliferator-activated receptor gamma, co-activator 1 alpha | PPARGC1A | −3.7 | 0.021 |
| Protein phosphatase 2, regulatory subunit a, beta | PPP2R1B | −5.3 | 0.027 |
| Retinoic acid receptor, alpha | RARA | −2.7 | 0.030 |
| Related RAS viral (R-Ras) oncogene homolog 2 | RRAS2 | 2.2 | 0.039 |
| Retinoid X receptor, gamma | RXRG | −2.3 | 0.049 |
| Sp1 transcription factor | SP1 | −1.9 | 0.047 |
| SRC proto-oncogene, non-receptor tyrosine kinase | SRC | 2.8 | 0.024 |
| Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | UCHL1 | 4.6 | 0.01 |
| UDP glucuronosyltransferase 1 family, polypeptide A1 | UGT1A1 | 17.9 | 0.008 |
| UDP glucuronosyltransferase 1 family, polypeptide A3 | UGT1A3 | 3.0 | 0.037 |
| UDP glucuronosyltransferase 1 family, polypeptide A4 | UGT1A4 | 7.8 | 0.021 |
| UDP glucuronosyltransferase 1 family, polypeptide A6 | UGT1A6 | 10.2 | 0.024 |
| UDP glucuronosyltransferase 2 family, polypeptide A3 | UGT2A3 | 6.4 | 0.01 |
| UDP glucuronosyltransferase 2 family, polypeptide B11 | UGT2B11 | 4.4 | 0.011 |
| UDP glucuronosyltransferase 2 family, polypeptide B15 | UGT2B15 | 11.0 | 0.011 |
| UDP glucuronosyltransferase 2 family, polypeptide B17 | UGT2B17 | 7.3 | 0.012 |
| UDP glucuronosyltransferase 2 family, polypeptide B4 | UGT2B4 | 4.1 | 0.019 |
| UDP glucuronosyltransferase 2 family, polypeptide B7 | UGT2B7 | 2.2 | 0.033 |