Fig. 5.

In vivo dose–response curves for developmental toxicity of phenol (solid black line), p-fluorophenol (solid grey line), p-heptyloxyphenol (dashed line) and p-methylketophenol (dotted line) in rat predicted by in vitro PBK-based reverse dosimetry. a Represents the predicted dose–response curves based on the nominal test concentration of the phenols relating C _max to developmental toxicity. b Represents the predicted dose–response curves relating the AUC_0–10d of the phenols to developmental toxicity