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. 2017 Apr 21;8:653. doi: 10.3389/fmicb.2017.00653

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Copyright © 2017 Nealon, Yuan, Yang and Ryan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytoscape network analysis of select lipid pathways in the large intestinal contents when comparing Probiotic + Rice Bran and Probiotic. Cytoscape visualization of lipid metabolites in LIC metabolic pathways associated with anti-diarrheal activity across Pro+RB and Pro. For each metabolite, node diameter is proportional to the magnitude of the fold difference in Pro+RB compared to Pro. Node color indicates the direction of a metabolite’s fold difference: red indicates metabolites with a higher scaled abundance in Pro+RB (p < 0.05), blue indicates lower abundance in Pro+RB (p < 0.05), pink indicates trending higher in Pro+RB (0.05 < p < 0.10), and light blue indicates trending lower in Pro+RB (0.05 < p < 0.10). Black nodes indicate metabolites with fold differences that were not significantly altered between treatments. The pathway enrichment score is the number in the circle for each pathway.