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. 2017 Apr 21;7:137. doi: 10.3389/fcimb.2017.00137

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Copyright © 2017 Camassa, Palucci, Iantomasi, Cubeddu, Minerva, De Maio, Jouny, Petruccioli, Goletti, Ria, Sali, Sanguinetti, Manganelli, Rocca, Brodin and Delogu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polymorphisms in pe_pgr33 do not affect the immunomodulatory properties of the protein in in vitro human MDMs infections. Supernatants collected at 72 h post-infection were assessed for TNF-α and IL-1β. For all Mtb strains, each symbol corresponds to the mean of triplicates obtained from MDMs infections of 4 healthy donors. Bars indicate the median. None statistically significant difference was observed compared to Mtb H37Rv (Kruskal-Wallis one-way ANOVA followed by Dunnett's multiple comparison test).