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. 2017 Mar 6;292(16):6452–6460. doi: 10.1074/jbc.R116.771915

Figure 1.

Figure 1.

Environmental or pharmacological strategies to slow aging. Drugs such as rapamycin and STACs, and lifestyle interventions such as fasting or caloric restriction, alter the activity of the IIS, mTOR, and sirtuin pathways. This alteration induces a complex web of functional alterations that individually or collectively might slow the aging process.