Table 1.

A summary of some of the small molecules or approved and/or investigational drugs that may be beneficial to slow the aging process

Molecular target	Drug/Small molecule	Mode of action
Sirtuins	Resveratrol	? Direct/indirect STAC
	SRT1720/2104	Direct sirtuin activator
	Nicotinamide riboside	NAD precursor
	Apigenin	Inhibits CD38, enzyme that degrades NAD
mTOR	Rapamycin/Sirolimus/ Everolimus	Rapamycin and rapalogs/mTORC1 inhibitors
	AZD8055/INK128	Direct mTOR kinase inhibitors
IIS/GH	Pegvisomant	GH receptor antagonist
	Trametinib	Ras inhibitor resulting in decreased IIS signaling
AMPK and others	Metformin	Potential AMPK activator
	Ruxolitinib	JAK inhibitor/↓ inflammation
	Spermidine	Natural product ↑ autophagy
	Quescetin/Dasatinib	Senolytics