Figure 10.

Proposed model for the regulation of OGA during oxidative stress resulting in elevated levels of O-GlcNAc. O-GlcNAc levels become elevated during oxidative stress, and this is associated with cytoprotection. Counterintuitively, in U2OS cells exposed to oxidative stress, OGT activity remains constant, whereas OGA activity and expression are elevated. Our data support a model in which OGA forms complexes with other proteins (?), such as FAS, that regulate its activity leading to a stress-induced elevation of O-GlcNAc.