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Visualization of mutations in DsbB structure and binding prediction of pyridazinone inhibitors (compound 12). A, comparison of mutated residues in the structure of DsbB and in relation to ubiquinone. B, overlap of ubiquinone or menadione and compound 12 in the structure of DsbB. Residues studied in this work are highlighted in orange, DsbA in green, DsbB in cyan, Cys-44 in red, and ubiquinone-1 in purple. PyMOL was used to visualize the structure (2ZUP) of the crystallized complex.
