TABLE 4.

DsbB mutants give in vivo resistance against pyridazinone-related molecules

Values represent the average of three independent experiments with the 95% confidence intervals in parenthesis. Boldface numbers have more than a 2-fold increase compared with wild type. Underlined numbers have 1.8–1.9-fold increase of IC₅₀. Values that do not have a 95% confidence interval is due to the lack of higher concentrations tested given the poor solubility of some compounds in minimal media.

⁺ In vivo inhibition was measured by growth inhibition of strain lptD₄₂₁₃ ΔdsbB dsbB_Ptrc204 (CL409–10, CL416–7 and LI18–19 strains) in the presence of drugs.