CYP51 in sterol biosynthesis.
A, C. albicans CYP51 substrate lanosterol. B, products of the pathway in animals (cholesterol) and in fungi (ergosterol). C, three-step reaction of sterol 14α-demethylation. Each step involves one cycle of monooxygenation. 14α-Demethylation of lanosterol produces 4,4′-dimethylcholesta-8,14,24-triene-3β-ol (14α-desmethyllanosterol in Fig. 5).