Figure 10.

Superimposition of C. albicans and T. cruzi (gray) CYP51 complexes with posaconazole (PDB code 3K1O) and VT-1161 (PDB code 5AJR). A, posaconazole; B, VT-1161. Some phyla-specific residues that line the enzyme substrate-binding cavity, altering the conformation of the inhibitors, are shown as examples. A complete list of the corresponding ligand-contacting residues aligned in the fungal and protozoan CYP51 structures is shown in Table 2. Insets, C. albicans CYP51 in a surface representation (same view). The C-atoms of posaconazole and VT-1161 are colored in cyan and magenta, respectively.